A 50-year-old man was brought to the emergency department. He had sustained a burn affecting 55% of his total body surface area and a significant inhalational injury. In the emergency department he was intubated and ventilated, central venous, arterial and urinary catheters were placed and resuscitation begun using the Parkland formula.
He was transferred to burns intensive care. Fluid resuscitation was continued using Hartmann’s solution. A bronchoscopy was performed; 1.26% sodium bicarbonate was used for lavage. He became increasingly tachycardic and hypotensive. He was oliguric. His haematocrit was 0.45. Fluid status was difficult to assess clinically; he felt warm to touch. An oesophageal Doppler probe was sited which demonstrated low stroke volume and corrected flow time. His Doppler parameters improved with each 250ml bolus of Hartmann’s solution but the effect was short lived. Noradrenaline and then adrenaline infusions were used in an attempt to maintain blood pressure. After a significant volume of crystalloid had been given, approximately 12 hours after the time of injury, 4.5% human albumin solution was requested. This seemed to have a more prolonged effect than Hartmann’s solution. Over the next 12 hours the patient’s haemodynamic status stabilised and he was able to undergo initial surgical management of his burn 36 hours after presentation.
What is the evidence for the use of human albumin solution for fluid resuscitation in critically ill patients.Read More »